Currently genetically modified mice/rodents are being used to conduct research for Alzheimer's Disease. Researchers are making huge discoveries. The only problem, though, is that we do not any animals that have the same genes as humans. Even if it does work in mice, it might not work in humans. Researchers genetically modify mice to have Alzheimer's Disease. They monitor the different characteristic between normal mice and genetically altered mice. For example, the Alzheimer's mice dug less than an average mouse. The mice are used to test medication to see if it turns them back into normal acting mice. If it works on the mice, it would be worth it to try it on humans, but it is not guaranteed that it will work.
Alzheimer's Disease. (n.d.). Retrieved April 12, 2017, from http://www.understandinganimalresearch.org.uk/why/human-health/alzheimers-disease/ Dam, D. V., & Deyn, P. P. (2011, October). Animal models in the drug discovery pipeline for Alzheimer's disease. Retrieved April 11, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229762/ LaFerla, F. M., & Green, K. N. (2012, November). Animal Models of Alzheimer Disease. Retrieved April 12, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543097/
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According to Understanding Animal Research, in March 2012, Prime Minister David Cameron made a commitment to delivering major improvements in dementia care and research, doubling the budget for Alzheimer's research in the UK to £66 million. Some of this care and research will involve animals, and will build on the wealth of knowledge scientists have already gained from animal studies of the disease. Although the exact causes of Alzheimer’s remain unknown, monkeys and GM mice with Alzheimer’s-like brain abnormalities are helping scientists to unlock the secrets of the disease. These animals have been crucial in identifying molecules such as miR-34c that appear to play a role in disease development, and genetic mutations that confer susceptibility to Alzheimer’s. Animal models have also confirmed that head injuries, obesity and inactivity increase disease risk. Benefits.(n.d.).RetrievedApril12,2017,from http://www.understandinganimalresearch.org.uk/why/human-health/alzheimers-disease/ A. (2011, January 31). Retrieved April 12, 2017, from https://www.youtube.com/watch?v=A8ASyPT-F0g
Rodents and mice are primarily used as animal models for Alzheimer's Disease. The problem is that there are no animals that have the same exact genes as humans; regardless, researchers are making breakthrough discoveries, which can change the way Alzheimer patients manage with the crippling disease. Even if it does work in mice, it might not work in humans. Researchers genetically modify mice to mimic Alzheimer's Disease found in humans. They monitor for the different characteristic between normal mice and genetically altered mice. Subsequently, Alzheimer's mice dig less than an average mouse. The mice are used to test medication to see if it turns them back into normal acting mice. Moreover, if this research succeeds it would be very valuable to humans.
-Awa L. Dam, D. V., & Deyn, P. P. (2011, October). Animal models in the drug discovery pipeline for Alzheimer's disease. Retrieved April 11, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229762/ LaFerla, F. M., & Green, K. N. (2012, November). Animal Models of Alzheimer Disease. Retrieved April 12, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543097/ Alzheimer's Disease. (n.d.). Retrieved April 12, 2017, from http://www.understandinganimalresearch.org.uk/why/human-health/alzheimers-disease/ |
Heading Pictures: Should Animals Be Used for Scientific or Commercial Testing? [Digital image]. (2017, April 11). Retrieved April 25, 2017, from Blog, S. A. (2012). About Testing [Digital image]. Retrieved April 25, 2017, from https://sanchitsunny.wordpress.com/about-testing-2/
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